Combining mutants results in 5-fold lifespan extension in C. elegans

What are the limits to longevity? Scientists combined mutations in two pathways well-known for lifespan extension and report a synergistic five-fold lifespan extension in the nematode C. elegans. The worms lived to the human equivalent of 400 to 500 years. The research introduces the possibility of combination therapy for aging and could help explain why scientists are having a difficult time identifying single genes responsible for long lives in human centenarians.

by via ScienceDaily: Latest Science News